Drug interactions
Roflumilast + Voriconazole
Severity: Moderate
Roflumilast and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4 and CYP2C19, which contribute to roflumilast metabolism, so roflumilast and its active metabolite exposure may rise. This may increase adverse effects such as diarrhea, weight loss, headache and insomnia.
What this interaction means in plain words
Roflumilast and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Roflumilast belongs to Respiratory; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4 and CYP2C19, decreasing roflumilast clearance.
What to do
Monitor for roflumilast adverse effects and weight loss while on voriconazole; stop roflumilast if intolerable effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Roflumilast
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Roflumilast with Voriconazole?
MediHelp rates the interaction as moderate. Roflumilast and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole inhibits CYP3A4 and CYP2C19, which contribute to roflumilast metabolism, so roflumilast and its active metabolite exposure may rise. This may increase adverse effects such as diarrhea, weight loss, headache and insomnia.
How serious is the interaction between Roflumilast and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for roflumilast adverse effects and weight loss while on voriconazole; stop roflumilast if intolerable effects develop.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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