Drug interactions
Ropinirole + Rucaparib
Severity: Moderate
Ropinirole and Rucaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a moderate CYP1A2 inhibitor and may increase ropinirole concentrations. Dopaminergic adverse effects such as somnolence and orthostatic hypotension may become more pronounced.
What this interaction means in plain words
Ropinirole and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ropinirole belongs to Central Nervous System; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP1A2 metabolism of ropinirole.
What to do
Monitor for increased ropinirole effects and reduce the dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Ropinirole with Rucaparib?
MediHelp rates the interaction as moderate. Ropinirole and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib is a moderate CYP1A2 inhibitor and may increase ropinirole concentrations. Dopaminergic adverse effects such as somnolence and orthostatic hypotension may become more pronounced.
How serious is the interaction between Ropinirole and Rucaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased ropinirole effects and reduce the dose if needed.
What other medicines interact with Ropinirole?
MediHelp also lists interactions of Ropinirole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Ropinirole page.
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