Drug interactions
Ropinirole + Stiripentol
Severity: Moderate
Ropinirole and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol affects CYP1A2 activity and may alter ropinirole exposure unpredictably. Both drugs also cause somnolence, so sedation and dizziness may be additive.
What this interaction means in plain words
Ropinirole and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ropinirole belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol modulates CYP1A2 (inhibition and induction), changing ropinirole clearance, and both drugs add CNS depressant effects.
What to do
Monitor for sedation, somnolence and changes in symptom control after starting or stopping stiripentol. Adjust the ropinirole dose accordingly and advise caution when driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Ropinirole with Stiripentol?
MediHelp rates the interaction as moderate. Ropinirole and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol affects CYP1A2 activity and may alter ropinirole exposure unpredictably. Both drugs also cause somnolence, so sedation and dizziness may be additive.
How serious is the interaction between Ropinirole and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, somnolence and changes in symptom control after starting or stopping stiripentol. Adjust the ropinirole dose accordingly and advise caution when driving.
What other medicines interact with Ropinirole?
MediHelp also lists interactions of Ropinirole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Ropinirole page.
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