Drug interactions
Rosuvastatin + Tivozanib
Severity: Moderate
Rosuvastatin and Tivozanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tivozanib may inhibit BCRP in the gut and could raise rosuvastatin exposure, which increases the risk of statin-related muscle toxicity. The effect is predicted mainly from in vitro transporter data.
What this interaction means in plain words
Rosuvastatin and Tivozanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rosuvastatin belongs to Cardiovascular; Tivozanib belongs to Oncology.
Why it happens
Inhibition of intestinal BCRP efflux transport by tivozanib, which increases rosuvastatin absorption.
What to do
Consider using a statin that is not a BCRP substrate, or separate dosing by about 2 hours. Monitor for myalgia and muscle weakness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tivozanib
- Amobarbital + Tivozanib Major
- Carbamazepine + Tivozanib Major
- Phenytoin + Tivozanib Major
- Secobarbital + Tivozanib Major
- Apalutamide + Tivozanib Moderate
- Bosentan + Tivozanib Moderate
Other interactions of Rosuvastatin
Frequently asked questions
Can I take Rosuvastatin with Tivozanib?
MediHelp rates the interaction as moderate. Rosuvastatin and Tivozanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tivozanib may inhibit BCRP in the gut and could raise rosuvastatin exposure, which increases the risk of statin-related muscle toxicity. The effect is predicted mainly from in vitro transporter data.
How serious is the interaction between Rosuvastatin and Tivozanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider using a statin that is not a BCRP substrate, or separate dosing by about 2 hours. Monitor for myalgia and muscle weakness.
What other medicines interact with Tivozanib?
MediHelp also lists interactions of Tivozanib with, for example, Amobarbital, Carbamazepine, Phenytoin. The full list is on the Tivozanib page.
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