Drug interactions
Rosuvastatin + Warfarin
Severity: Moderate
Rosuvastatin and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rosuvastatin can raise the INR in patients on warfarin, sometimes significantly. The change often appears after starting or adjusting the statin dose.
What this interaction means in plain words
Rosuvastatin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rosuvastatin belongs to Cardiovascular; Warfarin belongs to Cardiovascular.
Why it happens
Mechanism unclear; possible effects on warfarin protein binding or clotting factor synthesis.
What to do
Check INR before starting rosuvastatin and frequently afterward, adjusting warfarin as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Rosuvastatin
Frequently asked questions
Can I take Rosuvastatin with Warfarin?
MediHelp rates the interaction as moderate. Rosuvastatin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rosuvastatin can raise the INR in patients on warfarin, sometimes significantly. The change often appears after starting or adjusting the statin dose.
How serious is the interaction between Rosuvastatin and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR before starting rosuvastatin and frequently afterward, adjusting warfarin as needed.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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