Drug interactions
Rozanolixizumab + Sarilumab
Severity: Moderate
Rozanolixizumab and Sarilumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rozanolixizumab blocks the neonatal Fc receptor, which normally recycles IgG antibodies and prolongs their half-life. Sarilumab is an IgG1 monoclonal antibody, so its exposure may fall and its efficacy in rheumatoid arthritis may diminish.
What this interaction means in plain words
Rozanolixizumab and Sarilumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rozanolixizumab belongs to Miscellaneous; Sarilumab belongs to Musculoskeletal.
Why it happens
FcRn blockade by rozanolixizumab increases lysosomal degradation of IgG-based drugs such as sarilumab, shortening their half-life.
What to do
Monitor disease activity for loss of sarilumab effect during rozanolixizumab treatment. If sustained sarilumab efficacy is essential, consider timing or alternative therapy decisions with the prescribing specialists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sarilumab
Other interactions of Rozanolixizumab
- Rozanolixizumab + Upadacitinib Major
- Abatacept + Rozanolixizumab Moderate
- Adalimumab + Rozanolixizumab Moderate
- Ado-trastuzumab + Rozanolixizumab Moderate
- Basiliximab + Rozanolixizumab Moderate
- Bevacizumab + Rozanolixizumab Moderate
Frequently asked questions
Can I take Rozanolixizumab with Sarilumab?
MediHelp rates the interaction as moderate. Rozanolixizumab and Sarilumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rozanolixizumab blocks the neonatal Fc receptor, which normally recycles IgG antibodies and prolongs their half-life. Sarilumab is an IgG1 monoclonal antibody, so its exposure may fall and its efficacy in rheumatoid arthritis may diminish.
How serious is the interaction between Rozanolixizumab and Sarilumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor disease activity for loss of sarilumab effect during rozanolixizumab treatment. If sustained sarilumab efficacy is essential, consider timing or alternative therapy decisions with the prescribing specialists.
What other medicines interact with Sarilumab?
MediHelp also lists interactions of Sarilumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Dengue vaccine. The full list is on the Sarilumab page.
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