Drug interactions
Rucaparib + Siponimod
Severity: Moderate
Rucaparib and Siponimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib can cause myelosuppression, including lymphopenia, and siponimod also lowers lymphocyte counts. Together they could increase susceptibility to infection, although direct data are lacking.
What this interaction means in plain words
Rucaparib and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rucaparib belongs to Oncology; Siponimod belongs to Central Nervous System.
Why it happens
Additive effects on blood counts: PARP inhibitor myelosuppression plus S1P receptor-mediated lymphocyte reduction.
What to do
Monitor complete blood counts including lymphocytes regularly. Hold or reassess therapy if severe cytopenia or infection develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Siponimod?
MediHelp rates the interaction as moderate. Rucaparib and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib can cause myelosuppression, including lymphopenia, and siponimod also lowers lymphocyte counts. Together they could increase susceptibility to infection, although direct data are lacking.
How serious is the interaction between Rucaparib and Siponimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts including lymphocytes regularly. Hold or reassess therapy if severe cytopenia or infection develops.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
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