Drug interactions
Rucaparib + Sorafenib
Severity: Minor
Rucaparib and Sorafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak inhibitor of CYP3A4 and may modestly raise sorafenib concentrations. Sorafenib is mainly cleared by CYP3A4 and UGT1A9, so the effect is likely small.
What this interaction means in plain words
Rucaparib and Sorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rucaparib belongs to Oncology; Sorafenib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4 by rucaparib reduces sorafenib metabolism.
What to do
No empirical dose change is needed. Monitor for sorafenib adverse effects such as hand-foot skin reaction, hypertension and diarrhea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sorafenib
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Sorafenib?
MediHelp rates the interaction as minor. Rucaparib and Sorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak inhibitor of CYP3A4 and may modestly raise sorafenib concentrations. Sorafenib is mainly cleared by CYP3A4 and UGT1A9, so the effect is likely small.
How serious is the interaction between Rucaparib and Sorafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor for sorafenib adverse effects such as hand-foot skin reaction, hypertension and diarrhea.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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