Drug interactions
Rucaparib + Tamoxifen
Severity: Moderate
Rucaparib and Tamoxifen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP3A4 and CYP2C9 (and CYP1A2, CYP2C19), which could alter tamoxifen metabolism. Effects on tamoxifen exposure and activation are not well characterized.
What this interaction means in plain words
Rucaparib and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rucaparib belongs to Oncology; Tamoxifen belongs to Endocrine.
Why it happens
Rucaparib inhibits CYP3A4 and CYP2C9, altering tamoxifen metabolism.
What to do
Monitor for tamoxifen adverse effects and efficacy. Adjust tamoxifen dose if clinically indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamoxifen
- Amiodarone + Tamoxifen Major
- Anastrozole + Tamoxifen Major
- Bupropion + Tamoxifen Major
- Carbamazepine + Tamoxifen Major
- Cinacalcet + Tamoxifen Major
- Dacomitinib + Tamoxifen Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Tamoxifen?
MediHelp rates the interaction as moderate. Rucaparib and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib inhibits CYP3A4 and CYP2C9 (and CYP1A2, CYP2C19), which could alter tamoxifen metabolism. Effects on tamoxifen exposure and activation are not well characterized.
How serious is the interaction between Rucaparib and Tamoxifen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tamoxifen adverse effects and efficacy. Adjust tamoxifen dose if clinically indicated.
What other medicines interact with Tamoxifen?
MediHelp also lists interactions of Tamoxifen with, for example, Amiodarone, Anastrozole, Bupropion. The full list is on the Tamoxifen page.
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