Drug interactions
Rucaparib + Tolterodine
Severity: Minor
Rucaparib and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a moderate CYP3A4 inhibitor and may increase tolterodine exposure. Since CYP2D6 is the main tolterodine pathway, the impact is greatest in CYP2D6 poor metabolizers or those on other inhibitors.
What this interaction means in plain words
Rucaparib and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rucaparib belongs to Oncology; Tolterodine belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4-mediated tolterodine metabolism by rucaparib.
What to do
Monitor for anticholinergic adverse effects and reduce the tolterodine dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Tolterodine?
MediHelp rates the interaction as minor. Rucaparib and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a moderate CYP3A4 inhibitor and may increase tolterodine exposure. Since CYP2D6 is the main tolterodine pathway, the impact is greatest in CYP2D6 poor metabolizers or those on other inhibitors.
How serious is the interaction between Rucaparib and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and reduce the tolterodine dose if they occur.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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