Drug interactions
Rucaparib + Tolvaptan
Severity: Moderate
Rucaparib and Tolvaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak-to-moderate inhibitor of CYP3A4 and may raise tolvaptan concentrations, which is a sensitive CYP3A4 substrate. Increased exposure can cause excessive aquaresis, thirst and too rapid sodium correction.
What this interaction means in plain words
Rucaparib and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rucaparib belongs to Oncology; Tolvaptan belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated tolvaptan metabolism by rucaparib.
What to do
Monitor serum sodium and volume status and consider lowering the tolvaptan dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Tolvaptan?
MediHelp rates the interaction as moderate. Rucaparib and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib is a weak-to-moderate inhibitor of CYP3A4 and may raise tolvaptan concentrations, which is a sensitive CYP3A4 substrate. Increased exposure can cause excessive aquaresis, thirst and too rapid sodium correction.
How serious is the interaction between Rucaparib and Tolvaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium and volume status and consider lowering the tolvaptan dose if adverse effects appear.
What other medicines interact with Tolvaptan?
MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.
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