Drug interactions
Rucaparib + Vincristine
Severity: Moderate
Rucaparib and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP3A4 to a modest degree and may raise vincristine exposure. This could increase neurotoxicity and gastrointestinal effects.
What this interaction means in plain words
Rucaparib and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rucaparib belongs to Oncology; Vincristine belongs to Oncology.
Why it happens
Rucaparib inhibits CYP3A4, reducing vincristine metabolism.
What to do
Monitor for neuropathy, constipation and myelosuppression. Reduce the vincristine dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Vincristine?
MediHelp rates the interaction as moderate. Rucaparib and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib inhibits CYP3A4 to a modest degree and may raise vincristine exposure. This could increase neurotoxicity and gastrointestinal effects.
How serious is the interaction between Rucaparib and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropathy, constipation and myelosuppression. Reduce the vincristine dose if toxicity appears.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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