Drug interactions
Rucaparib + Vinorelbine
Severity: Moderate
Rucaparib and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a reversible inhibitor of CYP3A4 in vitro and may modestly raise concentrations of vinorelbine. This could increase neutropenia and neurotoxicity, although clinical data are limited.
What this interaction means in plain words
Rucaparib and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rucaparib belongs to Oncology; Vinorelbine belongs to Oncology.
Why it happens
Rucaparib inhibition of CYP3A4 may reduce vinorelbine metabolism.
What to do
Monitor blood counts and for neuropathy or constipation. Reduce the vinorelbine dose if excess toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinorelbine
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Vinorelbine?
MediHelp rates the interaction as moderate. Rucaparib and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib is a reversible inhibitor of CYP3A4 in vitro and may modestly raise concentrations of vinorelbine. This could increase neutropenia and neurotoxicity, although clinical data are limited.
How serious is the interaction between Rucaparib and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for neuropathy or constipation. Reduce the vinorelbine dose if excess toxicity develops.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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