Drug interactions
Sacubitril-valsartan + Sotalol
Severity: Moderate
Sacubitril-valsartan and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sacubitril-valsartan and sotalol can both lower blood pressure, and the beta-blocker effect of sotalol may add to hypotension and bradycardia. Valsartan can raise potassium whereas sotalol is QT-prolonging, so any electrolyte disturbance matters for arrhythmia risk.
What this interaction means in plain words
Sacubitril-valsartan and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sacubitril-valsartan belongs to Cardiovascular; Sotalol belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering; potassium and renal changes from angiotensin receptor blockade may alter sotalol arrhythmic risk, and sotalol is renally cleared.
What to do
Monitor blood pressure, heart rate, ECG/QTc, potassium and renal function when starting or adjusting either drug. Reduce the sotalol dose if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Sacubitril-valsartan with Sotalol?
MediHelp rates the interaction as moderate. Sacubitril-valsartan and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sacubitril-valsartan and sotalol can both lower blood pressure, and the beta-blocker effect of sotalol may add to hypotension and bradycardia. Valsartan can raise potassium whereas sotalol is QT-prolonging, so any electrolyte disturbance matters for arrhythmia risk.
How serious is the interaction between Sacubitril-valsartan and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate, ECG/QTc, potassium and renal function when starting or adjusting either drug. Reduce the sotalol dose if renal function declines.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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