Drug interactions
Sacubitril-valsartan + Vadadustat
Severity: Moderate
Sacubitril-valsartan and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat is a substrate of renal and hepatic organic anion transporters, and drugs that inhibit these transporters can raise its exposure. Higher vadadustat levels could cause an excessive or overly rapid rise in hemoglobin and more adverse effects such as thrombotic events or hypertension.
What this interaction means in plain words
Sacubitril-valsartan and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sacubitril-valsartan belongs to Cardiovascular; Vadadustat belongs to Endocrine.
Why it happens
Possible inhibition of OAT1/OAT3-mediated transport of vadadustat, increasing its systemic exposure.
What to do
Monitor hemoglobin regularly and adjust the vadadustat dose per labeling if the rise is too rapid. Watch for hypertension and thrombotic events.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Sacubitril-valsartan with Vadadustat?
MediHelp rates the interaction as moderate. Sacubitril-valsartan and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat is a substrate of renal and hepatic organic anion transporters, and drugs that inhibit these transporters can raise its exposure. Higher vadadustat levels could cause an excessive or overly rapid rise in hemoglobin and more adverse effects such as thrombotic events or hypertension.
How serious is the interaction between Sacubitril-valsartan and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin regularly and adjust the vadadustat dose per labeling if the rise is too rapid. Watch for hypertension and thrombotic events.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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