Drug interactions
Safinamide + Trazodone
Severity: Contraindicated
Safinamide and Trazodone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Safinamide is a reversible MAO-B inhibitor, and combining it with trazodone may precipitate serotonin syndrome. Safinamide labeling contraindicates use with antidepressants of this type.
What this interaction means in plain words
Safinamide and Trazodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Safinamide belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive serotonergic activity from MAO-B inhibition plus trazodone's serotonin reuptake inhibition.
What to do
Avoid the combination. Allow at least 14 days after stopping safinamide before starting trazodone, and allow an adequate washout of trazodone before starting safinamide.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Safinamide with Trazodone?
MediHelp rates the interaction as contraindicated. Safinamide and Trazodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Safinamide is a reversible MAO-B inhibitor, and combining it with trazodone may precipitate serotonin syndrome. Safinamide labeling contraindicates use with antidepressants of this type.
How serious is the interaction between Safinamide and Trazodone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Allow at least 14 days after stopping safinamide before starting trazodone, and allow an adequate washout of trazodone before starting safinamide.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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