Drug interactions
Safinamide + Trimipramine
Severity: Contraindicated
Safinamide and Trimipramine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Safinamide is a MAO-B inhibitor, and tricyclic antidepressants can precipitate serotonin syndrome or blood pressure changes when combined with it. Labeling for safinamide contraindicates antidepressants of this type.
What this interaction means in plain words
Safinamide and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Safinamide belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
MAO-B inhibition with tricyclic monoamine reuptake blockade increases serotonergic and noradrenergic activity.
What to do
Do not co-administer. Observe the labeled washout periods when switching between the drugs.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Safinamide with Trimipramine?
MediHelp rates the interaction as contraindicated. Safinamide and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Safinamide is a MAO-B inhibitor, and tricyclic antidepressants can precipitate serotonin syndrome or blood pressure changes when combined with it. Labeling for safinamide contraindicates antidepressants of this type.
How serious is the interaction between Safinamide and Trimipramine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Observe the labeled washout periods when switching between the drugs.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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