Drug interactions
Salmeterol + Stiripentol
Severity: Moderate
Salmeterol and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and induces several CYP enzymes, including CYP3A4, so its effect on salmeterol exposure is unpredictable. Increased exposure could cause tachycardia and QT effects, while reduced exposure could weaken bronchodilation.
What this interaction means in plain words
Salmeterol and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Salmeterol belongs to Respiratory; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed inhibition and induction of CYP3A4 by stiripentol alters salmeterol metabolism.
What to do
Monitor respiratory control and cardiovascular adverse effects when stiripentol is started, changed or stopped. Adjust the respiratory regimen based on response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Salmeterol with Stiripentol?
MediHelp rates the interaction as moderate. Salmeterol and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits and induces several CYP enzymes, including CYP3A4, so its effect on salmeterol exposure is unpredictable. Increased exposure could cause tachycardia and QT effects, while reduced exposure could weaken bronchodilation.
How serious is the interaction between Salmeterol and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory control and cardiovascular adverse effects when stiripentol is started, changed or stopped. Adjust the respiratory regimen based on response.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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