Drug interactions
Salmeterol + Tiotropium-olodaterol
Severity: Major
Salmeterol and Tiotropium-olodaterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salmeterol is another long-acting beta2 agonist, so combining it with olodaterol duplicates therapy and increases the risk of tachycardia, tremor, hypokalemia and arrhythmia. It provides no added benefit.
What this interaction means in plain words
Salmeterol and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Salmeterol belongs to Respiratory; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Duplicate beta2-adrenergic receptor agonism producing additive adrenergic effects.
What to do
Avoid concurrent use of two long-acting beta2 agonists. Use a single LABA and review the regimen.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tiotropium-olodaterol
Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Salmeterol with Tiotropium-olodaterol?
MediHelp rates the interaction as major. Salmeterol and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Salmeterol is another long-acting beta2 agonist, so combining it with olodaterol duplicates therapy and increases the risk of tachycardia, tremor, hypokalemia and arrhythmia. It provides no added benefit.
How serious is the interaction between Salmeterol and Tiotropium-olodaterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two long-acting beta2 agonists. Use a single LABA and review the regimen.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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