Drug interactions
Salmeterol + Trazodone
Severity: Moderate
Salmeterol and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone can prolong QT and cause orthostatic hypotension, while salmeterol can cause tachycardia and hypokalemia. Together they may increase the risk of arrhythmia, though the clinical evidence is limited.
What this interaction means in plain words
Salmeterol and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Salmeterol belongs to Respiratory; Trazodone belongs to Central Nervous System.
Why it happens
Additive QT prolongation and hemodynamic effects; trazodone is not a typical tricyclic reuptake inhibitor of norepinephrine.
What to do
Monitor heart rate and ECG in patients with cardiac disease or other QT risk factors, and correct potassium and magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Salmeterol with Trazodone?
MediHelp rates the interaction as moderate. Salmeterol and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone can prolong QT and cause orthostatic hypotension, while salmeterol can cause tachycardia and hypokalemia. Together they may increase the risk of arrhythmia, though the clinical evidence is limited.
How serious is the interaction between Salmeterol and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG in patients with cardiac disease or other QT risk factors, and correct potassium and magnesium.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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