Drug interactions
Saquinavir + Vilazodone
Severity: Moderate
Saquinavir and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saquinavir, usually given with ritonavir, inhibits CYP3A4 and may increase vilazodone levels. Saquinavir also prolongs QT, though that is not part of this interaction.
What this interaction means in plain words
Saquinavir and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated vilazodone metabolism.
What to do
Monitor for adverse effects and reduce vilazodone to 20 mg daily if intolerable effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Saquinavir with Vilazodone?
MediHelp rates the interaction as moderate. Saquinavir and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Saquinavir, usually given with ritonavir, inhibits CYP3A4 and may increase vilazodone levels. Saquinavir also prolongs QT, though that is not part of this interaction.
How serious is the interaction between Saquinavir and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects and reduce vilazodone to 20 mg daily if intolerable effects occur.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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