Drug interactions
Saxagliptin + Voxelotor
Severity: Minor
Saxagliptin and Voxelotor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and may raise concentrations of its substrates, including saxagliptin. Saxagliptin has a wide safety margin, so a clinically important effect is not expected for most patients.
What this interaction means in plain words
Saxagliptin and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Saxagliptin belongs to Endocrine; Voxelotor belongs to Miscellaneous.
Why it happens
Moderate CYP3A4 inhibition by voxelotor reduces saxagliptin metabolism.
What to do
No routine dose change is needed. Monitor glucose control and tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Saxagliptin with Voxelotor?
MediHelp rates the interaction as minor. Saxagliptin and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voxelotor inhibits CYP3A4 and may raise concentrations of its substrates, including saxagliptin. Saxagliptin has a wide safety margin, so a clinically important effect is not expected for most patients.
How serious is the interaction between Saxagliptin and Voxelotor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor glucose control and tolerability.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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