Drug interactions
Saxagliptin + Zafirlukast
Severity: Minor
Saxagliptin and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saxagliptin is metabolized by CYP3A4/5, and its dose is reduced with strong inhibitors. Zafirlukast is not a strong inhibitor, so a relevant increase is unlikely.
What this interaction means in plain words
Saxagliptin and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Saxagliptin belongs to Endocrine; Zafirlukast belongs to Respiratory.
Why it happens
Possible weak CYP3A4 inhibition by zafirlukast reducing saxagliptin clearance.
What to do
No dose adjustment is required. Monitor glycemic control as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Saxagliptin with Zafirlukast?
MediHelp rates the interaction as minor. Saxagliptin and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Saxagliptin is metabolized by CYP3A4/5, and its dose is reduced with strong inhibitors. Zafirlukast is not a strong inhibitor, so a relevant increase is unlikely.
How serious is the interaction between Saxagliptin and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Monitor glycemic control as usual.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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