Drug interactions
Saxagliptin-metformin + Tacrolimus
Severity: Moderate
Saxagliptin-metformin and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus is diabetogenic and can raise blood glucose, which can undermine control with saxagliptin-metformin. Tacrolimus nephrotoxicity may also affect metformin clearance.
What this interaction means in plain words
Saxagliptin-metformin and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Saxagliptin-metformin belongs to Endocrine; Tacrolimus belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism from tacrolimus-induced impaired insulin secretion, with possible renal impairment reducing metformin clearance.
What to do
Monitor glucose and renal function regularly. Adjust antidiabetic therapy and stop metformin if renal function declines markedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Saxagliptin-metformin with Tacrolimus?
MediHelp rates the interaction as moderate. Saxagliptin-metformin and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus is diabetogenic and can raise blood glucose, which can undermine control with saxagliptin-metformin. Tacrolimus nephrotoxicity may also affect metformin clearance.
How serious is the interaction between Saxagliptin-metformin and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and renal function regularly. Adjust antidiabetic therapy and stop metformin if renal function declines markedly.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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