Drug interactions
Saxagliptin-metformin + Tipranavir
Severity: Moderate
Saxagliptin-metformin and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir is co-administered with ritonavir, a strong CYP3A4 inhibitor, which can raise saxagliptin exposure. Protease inhibitors may also cause insulin resistance and hyperglycemia, opposing metformin.
What this interaction means in plain words
Saxagliptin-metformin and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Saxagliptin-metformin belongs to Endocrine; Tipranavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted CYP3A4 inhibition reduces saxagliptin clearance, while protease inhibitor-related insulin resistance opposes metformin.
What to do
Limit saxagliptin to 2.5 mg daily and monitor blood glucose, adjusting therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Saxagliptin-metformin with Tipranavir?
MediHelp rates the interaction as moderate. Saxagliptin-metformin and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir is co-administered with ritonavir, a strong CYP3A4 inhibitor, which can raise saxagliptin exposure. Protease inhibitors may also cause insulin resistance and hyperglycemia, opposing metformin.
How serious is the interaction between Saxagliptin-metformin and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit saxagliptin to 2.5 mg daily and monitor blood glucose, adjusting therapy as needed.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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