Drug interactions
Saxagliptin-metformin + Trimethoprim
Severity: Moderate
Saxagliptin-metformin and Trimethoprim: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimethoprim inhibits renal tubular transporters OCT2 and MATE1, raising metformin plasma levels. This may increase the risk of metformin adverse effects, including lactic acidosis, especially in renal impairment.
What this interaction means in plain words
Saxagliptin-metformin and Trimethoprim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Saxagliptin-metformin belongs to Endocrine; Trimethoprim belongs to Anti Bacterial.
Why it happens
Inhibition of OCT2/MATE1-mediated renal tubular secretion reduces metformin clearance.
What to do
Monitor renal function and for metformin toxicity, and consider reducing the metformin dose, particularly if eGFR is reduced or treatment is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Trimethoprim
Frequently asked questions
Can I take Saxagliptin-metformin with Trimethoprim?
MediHelp rates the interaction as moderate. Saxagliptin-metformin and Trimethoprim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimethoprim inhibits renal tubular transporters OCT2 and MATE1, raising metformin plasma levels. This may increase the risk of metformin adverse effects, including lactic acidosis, especially in renal impairment.
How serious is the interaction between Saxagliptin-metformin and Trimethoprim?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and for metformin toxicity, and consider reducing the metformin dose, particularly if eGFR is reduced or treatment is prolonged.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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