Drug interactions
Saxagliptin-metformin + Vemurafenib
Severity: Minor
Saxagliptin-metformin and Vemurafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib inhibits P-glycoprotein and may raise saxagliptin concentrations. Saxagliptin is only a modest P-gp substrate, so the effect is expected to be small. Vemurafenib also moderately induces CYP3A4, which could offset this.
What this interaction means in plain words
Saxagliptin-metformin and Vemurafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Saxagliptin-metformin belongs to Endocrine; Vemurafenib belongs to Oncology.
Why it happens
P-gp inhibition by vemurafenib may reduce saxagliptin efflux.
What to do
No dose change is routinely needed; monitor glycemic response and tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Vemurafenib
Frequently asked questions
Can I take Saxagliptin-metformin with Vemurafenib?
MediHelp rates the interaction as minor. Saxagliptin-metformin and Vemurafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vemurafenib inhibits P-glycoprotein and may raise saxagliptin concentrations. Saxagliptin is only a modest P-gp substrate, so the effect is expected to be small. Vemurafenib also moderately induces CYP3A4, which could offset this.
How serious is the interaction between Saxagliptin-metformin and Vemurafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; monitor glycemic response and tolerability.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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