Drug interactions
Saxagliptin-metformin + Vorinostat
Severity: Minor
Saxagliptin-metformin and Vorinostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorinostat can cause hyperglycemia, which may reduce the effect of antidiabetic therapy. The interaction is pharmacodynamic and mainly relevant in diabetic patients.
What this interaction means in plain words
Saxagliptin-metformin and Vorinostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Saxagliptin-metformin belongs to Endocrine; Vorinostat belongs to Oncology.
Why it happens
Vorinostat-associated hyperglycemia opposes glucose-lowering therapy; the mechanism is not well established.
What to do
Monitor blood glucose during vorinostat treatment and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Saxagliptin-metformin and Vorinostat, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Saxagliptin-metformin
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Saxagliptin-metformin with Vorinostat?
MediHelp rates the interaction as minor. Saxagliptin-metformin and Vorinostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vorinostat can cause hyperglycemia, which may reduce the effect of antidiabetic therapy. The interaction is pharmacodynamic and mainly relevant in diabetic patients.
How serious is the interaction between Saxagliptin-metformin and Vorinostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during vorinostat treatment and adjust antidiabetic therapy as needed.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
