Drug interactions
Scopolamine + Tiotropium-olodaterol
Severity: Moderate
Scopolamine and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Scopolamine is a potent antimuscarinic, and combining it with tiotropium adds to anticholinergic effects such as dry mouth, constipation, urinary retention, blurred vision, and confusion. Systemic scopolamine effects are of most concern in older patients.
What this interaction means in plain words
Scopolamine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Scopolamine belongs to Respiratory; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for anticholinergic effects, especially in the elderly and those with glaucoma or urinary retention. Consider an alternative antiemetic if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Scopolamine
Frequently asked questions
Can I take Scopolamine with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Scopolamine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Scopolamine is a potent antimuscarinic, and combining it with tiotropium adds to anticholinergic effects such as dry mouth, constipation, urinary retention, blurred vision, and confusion. Systemic scopolamine effects are of most concern in older patients.
How serious is the interaction between Scopolamine and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, especially in the elderly and those with glaucoma or urinary retention. Consider an alternative antiemetic if symptoms develop.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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