Drug interactions
Scopolamine + Trazodone
Severity: Minor
Scopolamine and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone has little anticholinergic activity but is strongly sedating, so combining it with scopolamine mainly adds to drowsiness, dizziness and impaired psychomotor performance. A mild increase in antimuscarinic effects such as dry mouth is possible.
What this interaction means in plain words
Scopolamine and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Scopolamine belongs to Respiratory; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS depression with a small additive antimuscarinic effect.
What to do
Counsel patients about drowsiness and caution with driving. Monitor for confusion in older patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Scopolamine and Trazodone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Scopolamine
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Scopolamine with Trazodone?
MediHelp rates the interaction as minor. Scopolamine and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trazodone has little anticholinergic activity but is strongly sedating, so combining it with scopolamine mainly adds to drowsiness, dizziness and impaired psychomotor performance. A mild increase in antimuscarinic effects such as dry mouth is possible.
How serious is the interaction between Scopolamine and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and caution with driving. Monitor for confusion in older patients.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
