Drug interactions
Scopolamine + Trimipramine
Severity: Moderate
Scopolamine and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is a sedating tricyclic with significant anticholinergic effects, so scopolamine can add to dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion. Sedation is also additive, and older patients are especially vulnerable to delirium.
What this interaction means in plain words
Scopolamine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Scopolamine belongs to Respiratory; Trimipramine belongs to Central Nervous System.
Why it happens
Additive muscarinic receptor blockade and CNS depression.
What to do
Monitor for anticholinergic toxicity and sedation, and avoid in older patients when possible. Reduce the dose or choose a less anticholinergic option if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Scopolamine with Trimipramine?
MediHelp rates the interaction as moderate. Scopolamine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine is a sedating tricyclic with significant anticholinergic effects, so scopolamine can add to dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion. Sedation is also additive, and older patients are especially vulnerable to delirium.
How serious is the interaction between Scopolamine and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and sedation, and avoid in older patients when possible. Reduce the dose or choose a less anticholinergic option if symptoms occur.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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