Drug interactions
Secobarbital + Voriconazole
Severity: Contraindicated
Secobarbital and Voriconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates are potent enzyme inducers and can greatly lower voriconazole concentrations, risking failure of antifungal therapy. Labeling contraindicates long-acting barbiturates, and short-acting ones are expected to behave similarly.
What this interaction means in plain words
Secobarbital and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Secobarbital belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
Induction of CYP2C19, CYP2C9 and CYP3A4, increasing voriconazole clearance.
What to do
Avoid the combination and use a non-inducing sedative-hypnotic. If unavoidable, monitor voriconazole trough levels and clinical response.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Secobarbital with Voriconazole?
MediHelp rates the interaction as contraindicated. Secobarbital and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Barbiturates are potent enzyme inducers and can greatly lower voriconazole concentrations, risking failure of antifungal therapy. Labeling contraindicates long-acting barbiturates, and short-acting ones are expected to behave similarly.
How serious is the interaction between Secobarbital and Voriconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing sedative-hypnotic. If unavoidable, monitor voriconazole trough levels and clinical response.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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