Drug interactions
Secukinumab + Smallpox vaccine live
Severity: Major
Secukinumab and Smallpox vaccine live: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Smallpox (vaccinia) vaccine contains replicating live virus that can spread or cause progressive vaccinia in immunocompromised people. Secukinumab may reduce the vaccine response and theoretically increase this risk.
What this interaction means in plain words
Secukinumab and Smallpox vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Immunomodulation by IL-17A blockade may reduce immunogenicity and impair control of replicating vaccinia virus.
What to do
Avoid vaccination during secukinumab therapy unless there is a high exposure risk, and seek infectious disease advice. Vaccinate before starting treatment where possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Secukinumab
- Adenovirus types 4 and 7 live + Secukinumab Major
- Bcg vaccine live + Secukinumab Major
- Influenza virus vaccine quadrivalent intranasal + Secukinumab Major
- Measles mumps and rubella vaccine live + Secukinumab Major
- Measles mumps and rubella vaccine + Secukinumab Major
- Measles mumps rubella and varicella vaccine live + Secukinumab Major
Frequently asked questions
Can I take Secukinumab with Smallpox vaccine live?
MediHelp rates the interaction as major. Secukinumab and Smallpox vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Smallpox (vaccinia) vaccine contains replicating live virus that can spread or cause progressive vaccinia in immunocompromised people. Secukinumab may reduce the vaccine response and theoretically increase this risk.
How serious is the interaction between Secukinumab and Smallpox vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid vaccination during secukinumab therapy unless there is a high exposure risk, and seek infectious disease advice. Vaccinate before starting treatment where possible.
What other medicines interact with Secukinumab?
MediHelp also lists interactions of Secukinumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Secukinumab page.
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