Drug interactions
Secukinumab + Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine
Severity: Minor
Secukinumab and Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secukinumab may theoretically blunt the response to Tdap, although studies with tetanus toxoid vaccine during secukinumab therapy showed adequate antibody responses. Inactivated vaccines are not contraindicated, but protection may be less certain than in untreated patients.
What this interaction means in plain words
Secukinumab and Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
IL-17A blockade may modulate vaccine immunogenicity, though tetanus responses appear largely preserved.
What to do
Update Tdap before starting secukinumab when feasible, but give it during treatment if due. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Secukinumab
- Adenovirus types 4 and 7 live + Secukinumab Major
- Bcg vaccine live + Secukinumab Major
- Influenza virus vaccine quadrivalent intranasal + Secukinumab Major
- Measles mumps and rubella vaccine live + Secukinumab Major
- Measles mumps and rubella vaccine + Secukinumab Major
- Measles mumps rubella and varicella vaccine live + Secukinumab Major
Frequently asked questions
Can I take Secukinumab with Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine?
MediHelp rates the interaction as minor. Secukinumab and Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Secukinumab may theoretically blunt the response to Tdap, although studies with tetanus toxoid vaccine during secukinumab therapy showed adequate antibody responses. Inactivated vaccines are not contraindicated, but protection may be less certain than in untreated patients.
How serious is the interaction between Secukinumab and Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Update Tdap before starting secukinumab when feasible, but give it during treatment if due. No routine dose change is needed.
What other medicines interact with Secukinumab?
MediHelp also lists interactions of Secukinumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Secukinumab page.
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