Drug interactions
Secukinumab + Typhoid polysaccharide vaccine
Severity: Minor
Secukinumab and Typhoid polysaccharide vaccine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The Vi polysaccharide typhoid vaccine is inactivated, not live, so there is no replication risk. Secukinumab might modestly reduce the antibody response, but this is not expected to be clinically important.
What this interaction means in plain words
Secukinumab and Typhoid polysaccharide vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible modest blunting of vaccine response from IL-17A blockade; no live organism is involved.
What to do
The vaccine can be given during secukinumab therapy. Ideally vaccinate before starting treatment when travel is planned.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Secukinumab and Typhoid polysaccharide vaccine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Secukinumab
- Adenovirus types 4 and 7 live + Secukinumab Major
- Bcg vaccine live + Secukinumab Major
- Influenza virus vaccine quadrivalent intranasal + Secukinumab Major
- Measles mumps and rubella vaccine live + Secukinumab Major
- Measles mumps and rubella vaccine + Secukinumab Major
- Measles mumps rubella and varicella vaccine live + Secukinumab Major
Frequently asked questions
Can I take Secukinumab with Typhoid polysaccharide vaccine?
MediHelp rates the interaction as minor. Secukinumab and Typhoid polysaccharide vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The Vi polysaccharide typhoid vaccine is inactivated, not live, so there is no replication risk. Secukinumab might modestly reduce the antibody response, but this is not expected to be clinically important.
How serious is the interaction between Secukinumab and Typhoid polysaccharide vaccine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: The vaccine can be given during secukinumab therapy. Ideally vaccinate before starting treatment when travel is planned.
What other medicines interact with Secukinumab?
MediHelp also lists interactions of Secukinumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Secukinumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
