Drug interactions
Secukinumab + Zoster vaccine recombinant
Severity: Minor
Secukinumab and Zoster vaccine recombinant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secukinumab is an immunomodulating biologic that might blunt the immune response to vaccination. The recombinant zoster vaccine is non-live, so it is safe to give, but protection may be somewhat reduced. Evidence for IL-17 inhibitors specifically is limited.
What this interaction means in plain words
Secukinumab and Zoster vaccine recombinant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Immunomodulation by IL-17A blockade may theoretically attenuate vaccine-induced immune responses.
What to do
Give the recombinant (non-live) zoster vaccine when indicated, ideally before starting or at a convenient point in secukinumab therapy. Do not delay needed vaccination solely because of secukinumab.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Secukinumab
- Adenovirus types 4 and 7 live + Secukinumab Major
- Bcg vaccine live + Secukinumab Major
- Influenza virus vaccine quadrivalent intranasal + Secukinumab Major
- Measles mumps and rubella vaccine live + Secukinumab Major
- Measles mumps and rubella vaccine + Secukinumab Major
- Measles mumps rubella and varicella vaccine live + Secukinumab Major
Frequently asked questions
Can I take Secukinumab with Zoster vaccine recombinant?
MediHelp rates the interaction as minor. Secukinumab and Zoster vaccine recombinant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Secukinumab is an immunomodulating biologic that might blunt the immune response to vaccination. The recombinant zoster vaccine is non-live, so it is safe to give, but protection may be somewhat reduced. Evidence for IL-17 inhibitors specifically is limited.
How serious is the interaction between Secukinumab and Zoster vaccine recombinant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the recombinant (non-live) zoster vaccine when indicated, ideally before starting or at a convenient point in secukinumab therapy. Do not delay needed vaccination solely because of secukinumab.
What other medicines interact with Secukinumab?
MediHelp also lists interactions of Secukinumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Secukinumab page.
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