Drug interactions
Selegiline + Sevoflurane
Severity: Moderate
Selegiline and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors may alter responses to volatile anesthetics, with possible labile blood pressure and autonomic instability. Evidence for selegiline is limited and the MAO-B selectivity reduces the risk.
What this interaction means in plain words
Selegiline and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Selegiline belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Pharmacodynamic interaction; MAO inhibition alters catecholamine handling and hemodynamics, though the mechanism is not well established.
What to do
Inform the anesthesiologist and monitor hemodynamics closely during surgery. Avoid indirect sympathomimetics and meperidine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Selegiline with Sevoflurane?
MediHelp rates the interaction as moderate. Selegiline and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors may alter responses to volatile anesthetics, with possible labile blood pressure and autonomic instability. Evidence for selegiline is limited and the MAO-B selectivity reduces the risk.
How serious is the interaction between Selegiline and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesiologist and monitor hemodynamics closely during surgery. Avoid indirect sympathomimetics and meperidine.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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