Drug interactions
Selegiline + Stiripentol
Severity: Moderate
Selegiline and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol can inhibit and induce CYP2B6, so selegiline exposure may change in either direction. This could alter efficacy or adverse effects.
What this interaction means in plain words
Selegiline and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Selegiline belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol modulates CYP2B6, which contributes to selegiline metabolism.
What to do
Monitor clinical response and adverse effects of selegiline when stiripentol is started or stopped. Adjust the selegiline dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Selegiline with Stiripentol?
MediHelp rates the interaction as moderate. Selegiline and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol can inhibit and induce CYP2B6, so selegiline exposure may change in either direction. This could alter efficacy or adverse effects.
How serious is the interaction between Selegiline and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and adverse effects of selegiline when stiripentol is started or stopped. Adjust the selegiline dose accordingly.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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