Drug interactions
Selegiline + Tedizolid
Severity: Moderate
Selegiline and Tedizolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tedizolid is an oxazolidinone with weak reversible MAO inhibition, and selegiline is an MAO-B inhibitor that loses selectivity at higher doses. The combination might raise the risk of serotonin toxicity or hypertension, though clinical data are lacking.
What this interaction means in plain words
Selegiline and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Selegiline belongs to Central Nervous System; Tedizolid belongs to Anti Bacterial.
Why it happens
Theoretical additive MAO inhibition and increased monoamine levels.
What to do
Prefer a non-oxazolidinone antibiotic; if both are needed, monitor blood pressure and for serotonin toxicity, especially with higher selegiline doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Selegiline with Tedizolid?
MediHelp rates the interaction as moderate. Selegiline and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tedizolid is an oxazolidinone with weak reversible MAO inhibition, and selegiline is an MAO-B inhibitor that loses selectivity at higher doses. The combination might raise the risk of serotonin toxicity or hypertension, though clinical data are lacking.
How serious is the interaction between Selegiline and Tedizolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-oxazolidinone antibiotic; if both are needed, monitor blood pressure and for serotonin toxicity, especially with higher selegiline doses.
What other medicines interact with Tedizolid?
MediHelp also lists interactions of Tedizolid with, for example, Bupropion, Cyproheptadine, Deferiprone. The full list is on the Tedizolid page.
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