Drug interactions
Selegiline + Trimipramine
Severity: Contraindicated
Selegiline and Trimipramine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline, especially at higher doses or in oral form, inhibits MAO and may cause serotonin syndrome or hypertensive crisis with tricyclics. Serious reactions have been reported.
What this interaction means in plain words
Selegiline and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Selegiline belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
MAO inhibition combined with tricyclic reuptake inhibition produces excessive monoaminergic stimulation.
What to do
Avoid concurrent use and allow at least 14 days after selegiline before trimipramine. Use a non-interacting antidepressant if needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Selegiline with Trimipramine?
MediHelp rates the interaction as contraindicated. Selegiline and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline, especially at higher doses or in oral form, inhibits MAO and may cause serotonin syndrome or hypertensive crisis with tricyclics. Serious reactions have been reported.
How serious is the interaction between Selegiline and Trimipramine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and allow at least 14 days after selegiline before trimipramine. Use a non-interacting antidepressant if needed.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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