Drug interactions
Selegiline transdermal + Teriflunomide
Severity: Minor
Selegiline transdermal and Teriflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide inhibits CYP2C8, but selegiline is metabolized mainly by CYP2B6, CYP2C19 and CYP3A4, with CYP2C8 playing a minor role. A meaningful interaction is not established, and the transdermal route bypasses first-pass metabolism.
What this interaction means in plain words
Selegiline transdermal and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical minor increase in selegiline exposure through CYP2C8 inhibition.
What to do
No dose adjustment is needed; monitor routinely for MAO inhibitor adverse effects such as blood pressure changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Teriflunomide
Frequently asked questions
Can I take Selegiline transdermal with Teriflunomide?
MediHelp rates the interaction as minor. Selegiline transdermal and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teriflunomide inhibits CYP2C8, but selegiline is metabolized mainly by CYP2B6, CYP2C19 and CYP3A4, with CYP2C8 playing a minor role. A meaningful interaction is not established, and the transdermal route bypasses first-pass metabolism.
How serious is the interaction between Selegiline transdermal and Teriflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor routinely for MAO inhibitor adverse effects such as blood pressure changes.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Lomustine, Amiodarone. The full list is on the Teriflunomide page.
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