Drug interactions
Tranylcypromine + Vilazodone
Severity: Contraindicated
Tranylcypromine and Vilazodone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilazodone with tranylcypromine can produce serotonin syndrome with hyperthermia, neuromuscular excitation and cardiovascular instability. This is a labeled contraindication.
What this interaction means in plain words
Tranylcypromine and Vilazodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Tranylcypromine belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Irreversible nonselective MAO inhibition combined with serotonin reuptake inhibition causes excess serotonergic stimulation.
What to do
Avoid entirely. Wait at least 14 days after stopping tranylcypromine before starting vilazodone, and at least 14 days after stopping vilazodone before starting tranylcypromine.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Tranylcypromine with Vilazodone?
MediHelp rates the interaction as contraindicated. Tranylcypromine and Vilazodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vilazodone with tranylcypromine can produce serotonin syndrome with hyperthermia, neuromuscular excitation and cardiovascular instability. This is a labeled contraindication.
How serious is the interaction between Tranylcypromine and Vilazodone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid entirely. Wait at least 14 days after stopping tranylcypromine before starting vilazodone, and at least 14 days after stopping vilazodone before starting tranylcypromine.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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