Drug interactions
Selexipag + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Moderate
Selexipag and Sofosbuvir-velpatasvir-voxilaprevir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxilaprevir inhibits the efflux transporter BCRP, which handles selexipag. Exposure to selexipag may rise, increasing prostacyclin-related adverse effects such as headache, flushing, jaw pain, nausea and hypotension.
What this interaction means in plain words
Selexipag and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Selexipag belongs to Cardiovascular; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
Why it happens
Voxilaprevir inhibits BCRP (ABCG2), reducing efflux of selexipag and possibly increasing its systemic exposure.
What to do
Monitor for prostacyclin-type adverse effects when starting the combination. Reduce the selexipag dose or titrate more slowly if effects are not tolerated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Selexipag
- Gemfibrozil + Selexipag Contraindicated
- Abiraterone + Selexipag Moderate
- Apalutamide + Selexipag Moderate
- Carbamazepine + Selexipag Moderate
- Clopidogrel + Selexipag Moderate
- Cyclosporin + Selexipag Moderate
Frequently asked questions
Can I take Selexipag with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as moderate. Selexipag and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxilaprevir inhibits the efflux transporter BCRP, which handles selexipag. Exposure to selexipag may rise, increasing prostacyclin-related adverse effects such as headache, flushing, jaw pain, nausea and hypotension.
How serious is the interaction between Selexipag and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for prostacyclin-type adverse effects when starting the combination. Reduce the selexipag dose or titrate more slowly if effects are not tolerated.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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