Drug interactions
Selinexor + Sertraline
Severity: Moderate
Selinexor and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion and other neurological effects, and sertraline can contribute to dizziness and sedation in some patients. No specific pharmacokinetic interaction is established, but overlapping adverse effects may add up.
What this interaction means in plain words
Selinexor and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Selinexor belongs to Oncology; Sertraline belongs to Central Nervous System.
Why it happens
Overlapping central nervous system adverse effects; no established pharmacokinetic mechanism.
What to do
Counsel patients to report dizziness or confusion and to avoid driving until the response is known. Reduce or hold selinexor per its labeling if neurological toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Selinexor with Sertraline?
MediHelp rates the interaction as moderate. Selinexor and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion and other neurological effects, and sertraline can contribute to dizziness and sedation in some patients. No specific pharmacokinetic interaction is established, but overlapping adverse effects may add up.
How serious is the interaction between Selinexor and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report dizziness or confusion and to avoid driving until the response is known. Reduce or hold selinexor per its labeling if neurological toxicity occurs.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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