Drug interactions
Selinexor + Vinblastine
Severity: Moderate
Selinexor and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause neurologic effects, and selinexor commonly causes dizziness, confusion and fatigue, while vinblastine can cause neuropathy. Additive nausea and myelosuppression may also occur, but no specific interaction mechanism is established.
What this interaction means in plain words
Selinexor and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Selinexor belongs to Oncology; Vinblastine belongs to Oncology.
Why it happens
Probable additive pharmacodynamic toxicity; no specific mechanism established.
What to do
Monitor for neurologic symptoms, cytopenias and gastrointestinal toxicity. Reduce doses or provide supportive care as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Selinexor with Vinblastine?
MediHelp rates the interaction as moderate. Selinexor and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause neurologic effects, and selinexor commonly causes dizziness, confusion and fatigue, while vinblastine can cause neuropathy. Additive nausea and myelosuppression may also occur, but no specific interaction mechanism is established.
How serious is the interaction between Selinexor and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neurologic symptoms, cytopenias and gastrointestinal toxicity. Reduce doses or provide supportive care as needed.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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