Drug interactions
Selumetinib + Ticlopidine
Severity: Moderate
Selumetinib and Ticlopidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selumetinib has been associated with hemorrhage and its labeling advises caution with antiplatelet agents. Ticlopidine, a potent antiplatelet drug, may add to the bleeding risk.
What this interaction means in plain words
Selumetinib and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Selumetinib belongs to Oncology; Ticlopidine belongs to Cardiovascular.
Why it happens
Additive bleeding risk from antiplatelet activity of ticlopidine and the bleeding tendency associated with selumetinib; selumetinib's mechanism is not well established.
What to do
Monitor for bleeding and blood counts, including platelets. Reassess the need for both agents if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Selumetinib and Ticlopidine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ticlopidine
Other interactions of Selumetinib
Frequently asked questions
Can I take Selumetinib with Ticlopidine?
MediHelp rates the interaction as moderate. Selumetinib and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selumetinib has been associated with hemorrhage and its labeling advises caution with antiplatelet agents. Ticlopidine, a potent antiplatelet drug, may add to the bleeding risk.
How serious is the interaction between Selumetinib and Ticlopidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and blood counts, including platelets. Reassess the need for both agents if bleeding occurs.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
