Drug interactions
Sertraline + Solifenacin
Severity: Minor
Sertraline and Solifenacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline has a small potential to prolong the QT interval, and solifenacin may add to this effect at higher doses. The overall clinical risk is low in patients without other risk factors.
What this interaction means in plain words
Sertraline and Solifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sertraline belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Possible additive effect on cardiac repolarization.
What to do
No routine action is needed in low-risk patients. Check an ECG if other QT-prolonging drugs, electrolyte problems or heart disease are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Solifenacin
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Sertraline with Solifenacin?
MediHelp rates the interaction as minor. Sertraline and Solifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sertraline has a small potential to prolong the QT interval, and solifenacin may add to this effect at higher doses. The overall clinical risk is low in patients without other risk factors.
How serious is the interaction between Sertraline and Solifenacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed in low-risk patients. Check an ECG if other QT-prolonging drugs, electrolyte problems or heart disease are present.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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