Drug interactions
Sertraline + Sonidegib
Severity: Minor
Sertraline and Sonidegib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sonidegib is metabolized mainly by CYP3A4. Sertraline is a weak CYP3A4 inhibitor, so any rise in sonidegib exposure is likely small. Increased sonidegib exposure could worsen musculoskeletal toxicity such as myalgia and creatine kinase elevation.
What this interaction means in plain words
Sertraline and Sonidegib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sertraline belongs to Central Nervous System; Sonidegib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4 by sertraline may slightly reduce sonidegib clearance.
What to do
No dose change is usually needed. Ask the patient about muscle pain or weakness and check creatine kinase if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Sonidegib
- Amiodarone + Sonidegib Major
- Apalutamide + Sonidegib Major
- Aprepitant + Sonidegib Major
- Armodafinil + Sonidegib Major
- Bosentan + Sonidegib Major
- Carbamazepine + Sonidegib Major
Frequently asked questions
Can I take Sertraline with Sonidegib?
MediHelp rates the interaction as minor. Sertraline and Sonidegib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sonidegib is metabolized mainly by CYP3A4. Sertraline is a weak CYP3A4 inhibitor, so any rise in sonidegib exposure is likely small. Increased sonidegib exposure could worsen musculoskeletal toxicity such as myalgia and creatine kinase elevation.
How serious is the interaction between Sertraline and Sonidegib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Ask the patient about muscle pain or weakness and check creatine kinase if symptoms occur.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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