Drug interactions
Sertraline + Tazemetostat
Severity: Minor
Sertraline and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a CYP3A4 substrate, and sertraline is at most a weak CYP3A4 inhibitor. Meaningful increases in tazemetostat exposure are not expected, in contrast with moderate inhibitors that require dose reduction.
What this interaction means in plain words
Sertraline and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sertraline belongs to Central Nervous System; Tazemetostat belongs to Miscellaneous.
Why it happens
Weak CYP3A4 inhibition by sertraline may marginally increase tazemetostat exposure.
What to do
No dose adjustment is usually required. Monitor for tazemetostat adverse effects as routine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Sertraline with Tazemetostat?
MediHelp rates the interaction as minor. Sertraline and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a CYP3A4 substrate, and sertraline is at most a weak CYP3A4 inhibitor. Meaningful increases in tazemetostat exposure are not expected, in contrast with moderate inhibitors that require dose reduction.
How serious is the interaction between Sertraline and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required. Monitor for tazemetostat adverse effects as routine.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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