Drug interactions
Sertraline + Vorinostat
Severity: Moderate
Sertraline and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorinostat has been associated with QT prolongation and sertraline has a small QT effect. Combined use may increase arrhythmia risk, especially if electrolytes are abnormal.
What this interaction means in plain words
Sertraline and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sertraline belongs to Central Nervous System; Vorinostat belongs to Oncology.
Why it happens
Additive QT interval prolongation.
What to do
Check ECG and electrolytes at baseline and periodically during therapy. Replace potassium and magnesium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Sertraline with Vorinostat?
MediHelp rates the interaction as moderate. Sertraline and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorinostat has been associated with QT prolongation and sertraline has a small QT effect. Combined use may increase arrhythmia risk, especially if electrolytes are abnormal.
How serious is the interaction between Sertraline and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes at baseline and periodically during therapy. Replace potassium and magnesium as needed.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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